Endocrine Abstracts

Introduction: Luteinizing hormone (LH) and human choriogonadotropin (hCG) regulate reproduction through binding the same receptor (LHCGR). They act via activation of G protein- and β-arrestin-dependent signals, resulting in ligand-specific pattern of signaling cascades and LHCGR internalization into endosomal vesicles. Previous studies differentiated the action of these two hormones in LH-related proliferative signals and hCG-related steroidogenic signals.Aim. We compared...

Introduction: Follicle-stimulating hormone (FSH) is a glycoprotein that support reproduction by regulating ovarian follicular growth and development. Recent studies demonstrated that proliferative signals mediating folliculogenesis are mediated by the G protein-coupled estrogen receptor (GPER) expressed in ovarian tissues throughout the follicular phase. In granulosa cells, GPER forms heteromers with FSHR, reprogramming cAMP-induced death signals to AKT-dependent, anti-apoptot...

Introduction: Type 5 phosphodiesterase (PDE5) inhibitors (PDE5i) lead to intracellular cyclic-guanosine monophosphate (cGMP) increase and are used for clinical treatment of erectile dysfunction. Studies found that cGMP may up/downregulate the growth of certain endocrine tumor cells, suggesting that the use of PDE5i could impact the risk of certain tumors, such as colorectal cancer.Aim: We evaluated if PDE5i may impact thyroid cancer cell growth in vi...